2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7203
    N-Caffeoyl O-methyltyramine 189307-47-9 98.52%
    N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM).
    N-Caffeoyl O-methyltyramine
  • HY-N7247
    Thiochrome 92-35-3 99.89%
    Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors.
    Thiochrome
  • HY-N7433
    4,6-O-Ethylidene-α-D-glucose 13224-99-2 98.0%
    4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport.
    4,6-O-Ethylidene-α-D-glucose
  • HY-N7439
    Mogroside VI B 2149606-17-5 98.97%
    Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription.
    Mogroside VI B
  • HY-N7511
    O-Nornuciferine 3153-55-7 99.85%
    O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor.
    O-Nornuciferine
  • HY-N7653
    Azaleatin 529-51-1 98.80%
    Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity.
    Azaleatin
  • HY-N7912
    Pterosin A 35910-16-8
    Pterosin A ((2S)-Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes.
    Pterosin A
  • HY-N8630
    Oleacein 149183-75-5
    Oleacein (Compound 9) is an ACE inhibitor that can be isolated from J. grandiflorum. Oleacein is orally active and can be used in the study of metabolic and cardiovascular diseases.
    Oleacein
  • HY-N9337
    Amaroswerin 21233-18-1 98.78%
    Amaroswerin is a bioactive secoiridoid glucoside from Swertia mussotii. Amaroswerin has anti-inflammatory, antidiabetic, antiviral, anticholinergic and immunomodulatory activities. Amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL in RAW264.7 cells.
    Amaroswerin
  • HY-N9783
    Procyanidin B2 3′-O-gallate 73086-04-1 98.27%
    Procyanidin B2 3′-O-gallate (B2-3′-G), isolated from Rhodiola crenulata extracts, is a potent xanthine oxidase (XO) inhibitor (IC50 = 24.24 μM, Ki = 6.16 μM). Procyanidin B2 3′-O-gallate has antioxidant activity and reduces the formation of UV-induced α-tocopheroxyl. Procyanidin B2 3′-O-gallate can be used for hyperuricemia and gout research.
    Procyanidin B2 3′-O-gallate
  • HY-N9959
    Isoengeletin 30987-58-7 99.28%
    Isoengeletin is a flavonoid that can be isolated from the roots of Smilax bockii warb. Isoengeletin can be used as an active compound for the research of psoriasis, hyperuricemia and gout.
    Isoengeletin
  • HY-P0104
    Palmitoyl tripeptide-38 1447824-23-8 99.83%
    Palmitoyl tripeptide-38 is a lipopeptide that increases the production of dermal and epidermal collagen, fibronectin, and hyaluronic acid. Palmitoyl tripeptide-38 is used in research related to skin aging (fine lines, wrinkles, reduced skin elasticity, decreased skin water content, uneven skin tone).
    Palmitoyl tripeptide-38
  • HY-P1067
    Enterostatin(human,mouse,rat) 117830-79-2 99.33%
    Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.
    Enterostatin(human,mouse,rat)
  • HY-P1228
    HAEGTFT 926018-95-3 98.81%
    HAEGTFT is the first N-terminal 1-7 residues of GLP-1 peptide.
    HAEGTFT
  • HY-P1252
    Parathyroid Hormone (1-34), bovine 12583-68-5 99.88%
    Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
    Parathyroid Hormone (1-34), bovine
  • HY-P1806
    Gastrin I (1-14), human 100940-57-6 98.25%
    Gastrin I (1-14), human is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion.
    Gastrin I (1-14), human
  • HY-P1822
    BDC2.5 mimotope 1040-31 329696-49-3 99.75%
    BDC2.5 mimotope 1040-31, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg+ T cells.
    BDC2.5 mimotope 1040-31
  • HY-P2844
    Polynucleotide kinase 37211-65-7
    Polynucleotide Kinase is a DNA repair enzyme. Polynucleotide Kinase possesses both a 5’-kinase activity that catalyzes the transfer of phosphate from ATP to a 5’-hydroxyl (OH) terminus and also a 3’-phosphatase activity that converts 3’-phosphate termini to 3’-OH termini.
    Polynucleotide kinase
  • HY-P2854
    Alanine dehydrogenase, expressed in E. coli 9029-06-5
    Alanine dehydrogenase, expressed in E. coli is a microbial enzyme that catalyzes a reversible conversion of L-alanine to pyruvate.
    Alanine dehydrogenase, expressed in E. coli
  • HY-P2859
    Chitosanase 51570-20-8
    Chitosanase is a glycosyl hydrolase that catalyzes the endo hydrolysis of β-1,4-glycosidic bonds of partially acetylated chitosan to release chitosan oligosaccharides (COS). Chitosanases can convert high molecular weight chitosan into functional chitooligosaccharides with low molecular weight.
    Chitosanase
Cat. No. Product Name / Synonyms Application Reactivity